کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3030163 | 1183174 | 2006 | 7 صفحه PDF | دانلود رایگان |
IntroductionSeveral experimental and clinical studies have demonstrated that platelet size and function correlate since large platelets are hemostatically more reactive than platelets of normal size. Since platelets play a crucial role in vascular remodeling after percutaneous transluminal coronary angioplasty (PTCA), we investigated the influence of the mean platelet volume (MPV), a parameter of platelet size, on restenosis after PTCA.MethodsThe retrospective study comprised 174 patients who underwent elective PTCA and follow-up angiography within 6 months thereafter. According to the follow-up angiograms, the patients were assigned to group A (“restenosis”, n = 74) or group B (“no restenosis”, n = 100). Both groups were compared in regard to pre-procedural hematological routine parameters including MPV, platelet count, hematocrit, white blood cell count and fibrinogen.ResultsMPV was significantly increased in group A, compared with that in group B (8.75 ± 0.99 fl vs. 8.04 ± 0.74 fl, p < 0.001). This difference in MPV was evident in patients with stable and unstable angina pectoris. In addition, MPV had an impact on the time-related incidence of angiographic restenosis, as early restenosis was associated with higher pre-procedural MPV values. Platelet count correlated inversely with MPV (r = −0.36, p < 0.01) and was significantly lower in group A than in group B. The remaining hematological parameters were not different in both groups.ConclusionsThe MPV seems to be a marker of coronary restenosis in patients undergoing PTCA. Patients with high pre-procedural MPV values might benefit from an intensified antiplatelet therapy after coronary interventions.
Journal: Thrombosis Research - Volume 117, Issue 4, 2006, Pages 371–377