کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3035101 1579556 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autonomic and cardiovascular responses to chemoreflex stress in apnoea divers
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Autonomic and cardiovascular responses to chemoreflex stress in apnoea divers
چکیده انگلیسی

Sleep apnoea, with repeated periods of hypoxia, results in cardiovascular morbidity and concomitant autonomic dysregulation. Trained apnoea divers also perform prolonged apnoeas accompanied by large lung volumes, large reductions in cardiac output and severe hypoxia and hypercapnia. We tested the hypothesis that apnoea training would be associated with decreased cardiovagal and sympathetic baroreflex gains and reduced respiratory modulation of muscle sympathetic nerve activity (MSNA; microneurography). Six trained divers and six controls were studied at rest and during asphyxic rebreathing. Despite an elevated resting heart rate (70 ± 14 vs. 56 ± 10 bpm; p = 0.038), divers had a similar cardiovagal baroreflex gain (−1.22 ± 0.47 beats/mmHg) as controls (−1.29 ± 0.61; NS). Similarly, though MSNA burst frequency was slightly higher in divers at rest (16 ± 4 bursts/min vs. 10 ± 5 bursts/min, p = 0.03) there was no difference in baseline burst incidence, sympathetic baroreflex gain (−3.8 ± 2.1%/mmHg vs. −4.7 ± 1.7%/mmHg) or respiratory modulation of MSNA between groups. Resting total peripheral resistance (11.9 ± 2.6 vs. 12.3 ± 2.2 mmHg/L/min) and pulse wave velocity (5.82 ± 0.55 vs. 6.10 ± 0.51 m/s) also were similar between divers and controls, respectively. Further, the sympathetic response to asphyxic rebreathing was not different between controls and divers (−1.70 ± 1.07 vs. −1.74 ± 0.84 a.u./% desaturation). Thus, these data suggest that, unlike patients with sleep apnoea, apnoea training in otherwise healthy individuals does not produce detectable autonomic dysregulation or maladaption.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 156, Issues 1–2, 25 August 2010, Pages 138–143
نویسندگان
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