کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3035162 1579558 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Atomoxetine changes rat's HR response to stress from tachycardia to bradycardia via alterations in autonomic function
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Atomoxetine changes rat's HR response to stress from tachycardia to bradycardia via alterations in autonomic function
چکیده انگلیسی

Atomoxetine is a central norepinephrine reuptake inhibitor used to treat attention deficit hyperactivity disorder. We tested the effects of atomoxetine upon the heart rate (HR) and mean arterial blood pressure (mBP) response to aversive conditioning. In Protocol 1 the mBP and HR responses to a stress (15 s tone followed by shock) were tested in 8 Sprague–Dawley rats given saline pretreatment for 3 days; the rats' responses were then tested for 3 additional days following atomoxetine (1 mg/kg, sc). Atomoxetine decreased (p < 0.05) baseline mBP from 128 ± 11 mm Hg (mean ± SD) to 117 ± 19 mm Hg; baseline HR slowed from 380 ± 23 bpm to 351 ± 21 bpm. The mBP increase to acute stress was similar after saline vs. after drug, but the peak was attained more slowly. After atomoxetine HR tended to slow during stress rather than accelerate. In Protocol 2 the cardiovascular responses were tested (n =  6) for 3 days post-saline and for 3 days after a higher dose of atomoxetine (2 mg/kg, sc). The average HR acceleration during the last 10 s of the stress after saline (+ 7.5 ± 14.7 bpm) was replaced by a HR slowing (− 6.2 ± 10.5 bpm). We conclude that drug treatment (a) decreases baseline sympathetic tone and/or elevates cardiac parasympathetic tone; (b) slows sympathetic arousal to acute stress without changing its magnitude; and, (c) enables the emergence of elevated parasympathetic tone during the stress. These autonomic consequences are consistent with atomoxetine's anxiolytic and transient sedative effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 154, Issues 1–2, 19 April 2010, Pages 48–53
نویسندگان
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