کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3035207 1184256 2009 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Generating diversity: Mechanisms regulating the differentiation of autonomic neuron phenotypes
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Generating diversity: Mechanisms regulating the differentiation of autonomic neuron phenotypes
چکیده انگلیسی

Sympathetic and parasympathetic postganglionic neurons innervate a wide range of target tissues. The subpopulation of neurons innervating each target tissue can express unique combinations of neurotransmitters, neuropeptides, ion channels and receptors, which together comprise the chemical phenotype of the neurons. The target-specific chemical phenotype shown by autonomic postganglionic neurons arises during development. In this review, we examine the different mechanisms that generate such a diversity of neuronal phenotypes from the pool of apparently homogenous neural crest progenitor cells that form the sympathetic ganglia. There is evidence that the final chemical phenotype of autonomic postganglionic neurons is generated by both signals at the level of the cell body that trigger cell-autonomous programs, as well as signals from the target tissues they innervate.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 151, Issue 1, 17 November 2009, Pages 17–29
نویسندگان
, ,