کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3035256 | 1184258 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adenosine modulates alpha2-adrenergic receptors through a phospholipase C pathway in brainstem cell culture of rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Adenosine modulates alpha2-adrenergic receptors through a phospholipase C pathway in brainstem cell culture of rats Adenosine modulates alpha2-adrenergic receptors through a phospholipase C pathway in brainstem cell culture of rats](/preview/png/3035256.png)
چکیده انگلیسی
Adenosine acts in the nucleus tractus solitarii (NTS), one of the main brain sites related to cardiovascular control. In the present study we show that A1 adenosine receptor (A1R) activation promotes an increase on alpha2-adrenoceptor (Alpha2R) binding in brainstem cell culture from newborn rats. We investigated the intracellular cascade involved in such modulatory process using different intracellular signaling molecule inhibitors as well as calcium chelators. Phospholipase C, protein kinase Ca2+-dependent, IP3 receptor and intracellular calcium were shown to participate in A1R/Alpha2R interaction. In conclusion, this result might be important to understand the role of adenosine within the NTS regarding autonomic cardiovascular control.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 151, Issue 2, 3 December 2009, Pages 174–177
Journal: Autonomic Neuroscience - Volume 151, Issue 2, 3 December 2009, Pages 174–177
نویسندگان
Daniel Carneiro Carrettiero, Sergio Marinho da Silva, Débora Rejane Fior-Chadi,