کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3046602 1185046 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Age dependence of primary motor cortex plasticity induced by paired associative stimulation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Age dependence of primary motor cortex plasticity induced by paired associative stimulation
چکیده انگلیسی

ObjectiveThe increase of elderly population prompted growing research for the understanding of cerebral phenomena sustaining learning abilities, with inclusion of long-term potentiation (LTP)-like plasticity phenomena. Aim of the present study was to characterize LTP-like plasticity dependence on age and gender.MethodsA LTP-like primary motor cortex plasticity inducing a potentiation of the motor evoked potential (MEP) to focal transcranial magnetic stimulation as a consequence of a paired associative stimulation (PAS) was induced in a 50 healthy subject cohort, equally distributed for gender and age groups (25 young subjects, mean age ± SD = 29.8 ± 4.5 years; elderly 61.1 ± 4.1 years).ResultsResting motor thresholds’ excitability level increased in the elderly group, the basal MEP did not depend on gender or age. The PAS-induced primary motor cortex (M1) plastic excitability modulation was similar in young females and males, while it decreased with age in females only.ConclusionsA reduction of the PAS-induced M1 plasticity in females after menopause was documented, possibly due to an impairment of intracortical excitatory network activity.SignificanceA LTP-like plasticity dependence on age was found in female only, suggesting caution in interpreting behavioural studies on learning abilities in dependence on age.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 119, Issue 3, March 2008, Pages 675–682
نویسندگان
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