کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3047130 1185053 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Combined cardiac sympathetic excitation and vagal impairment in patients with non-organic erectile dysfunction
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Combined cardiac sympathetic excitation and vagal impairment in patients with non-organic erectile dysfunction
چکیده انگلیسی

ObjectivePatients with non-organic erectile dysfunction (ED) frequently present with syndromes involving systemic sympathovagal dysfunction. The linkage of ED to cardiac autonomic regulation is not well understood.MethodsForty-four men with non-organic ED and 38 healthy age-matched control subjects with ages ranging from 40 years to 69 years were recruited. These two groups were divided into three distinct age categories at 10-year intervals. Patients were divided into three different severity categories, among whom 35 patients received a two-month oral treatment of trazodone. Power spectral analysis of successive R-R intervals (RR) was performed to evaluate the variance (variance of RR-interval values), the high-frequency power (HF), and the ratio of low-frequency power to HF (LF/HF) of their heart rate variability (HRV).ResultsPatients exhibited a significantly lower variance and HF, but a higher LF/HF compared to the control group across all age categories. The changes in variance and HF were severity dependent. In addition, all the HRV parameters of the patients with a satisfactory response after treatment have significantly improved.ConclusionThe results indicate that patients with non-organic ED had significant cardiac sympathetic hyperactivity and severity-dependent cardiac vagal impairment.SignificanceNon-organic ED may be accompanied by an abnormality in cardiac autonomic regulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 120, Issue 2, February 2009, Pages 348–352
نویسندگان
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