کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3047589 1185060 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Visual evoked potential latency, amplitude and habituation in migraine: A longitudinal study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Visual evoked potential latency, amplitude and habituation in migraine: A longitudinal study
چکیده انگلیسی

ObjectiveIt has not been previously studied with a paired longitudinal design if visual excitability changes occur in the preattack period across the migraine cycle, or how excitability and habituation relate to migraine-attack severity, clinical photophobia and serotonin metabolism.MethodsMonocular 62′ check reversals were applied in 33 adult migraine patients without aura (MwoA), 8 with aura (MA) and 31 controls. VEP was recorded in four blocks of 50 stimuli. P1 (P100) and N2 (N145) latency and N1P1 and P1N2 amplitude were measured. Serotonin was measured in plasma and platelets sampled before each session. Sessions were classified as preattack, attack, postattack or interictal.ResultsMigraine patients had significantly higher P1N2 amplitude before the attack compared to a paired interictal recording (n = 13, p = 0.03), but habituation difference was not found. MA patients had significantly higher P1N2 and N1P1 amplitude than controls and MwoA. P1 latency correlated positively with headache history duration. During attack, a positive correlation between P1N2 amplitude habituation and serotonin emerged in MA patients.ConclusionsIncreased VEP P1N2 amplitude was observed within a few days before the attack. Visual cortex excitability seems to be generally increased in MA as compared to MwoA patients and controls.SignificanceIncreased excitability of the visual cortex seems to be detectable in the preattack state, supporting the concept of a cyclic CNS dysfunction in migraine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 119, Issue 5, May 2008, Pages 1020–1027
نویسندگان
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