کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3048734 1185093 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
F wave study in amyotrophic lateral sclerosis: Assessment of balance between upper and lower motor neuron involvement
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
F wave study in amyotrophic lateral sclerosis: Assessment of balance between upper and lower motor neuron involvement
چکیده انگلیسی

ObjectiveWe sought to record significant F wave variable changes in ALS patients having no advanced disease. Furthermore, an interpretation of these F wave abnormalities in the context of upper (UMN) and lower motor neuron (LMN) dysfunction was attempted.MethodsStandard motor and sensory conduction study was performed to the ulnar nerves of 23 patients with ALS (13 males and 10 females with mean age 67.2±5.3 years), having a clinically predominant LMN syndrome. A series of 40 electrical stimuli were also delivered to both their ulnar nerves in order to obtain F waves. The following F wave variables were estimated: F persistence, F wave latency, amplitude, duration and F chronodispersion. Twenty-three, age-and gender-matched healthy volunteers served as controls.ResultsBoth the distal and proximal ulnar a-CMAPs (P=0.001) and the MCV (P=0.014) values were significantly decreased in patients, than the controls. The sensory conduction study was normal. The ulnar F wave persistence in the ALS patients was significantly lower than that of the controls (P=0.0007). The mean (P=0.0001), minimal (P=0.0001) and maximal (P=0.0001) F wave latencies were significantly prolonged, the F wave amplitudes (P=0.0001) were significantly higher and the F wave chronodispersion (P=0.014) was significantly increased in the patients than the controls.ConclusionsSignificant F wave abnormalities occur in patients with ALS, even those patients having no advanced disease. Increased F wave amplitudes combined with low persistence is a pattern consistent with ALS.SignificanceOur results show that patients with ALS having predominantly LMN involvement also have electrophysiological UMN dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 117, Issue 6, June 2006, Pages 1260–1265
نویسندگان
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