کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3051985 1579911 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vagus nerve stimulation in children less than 3 years with medically intractable epilepsy
ترجمه فارسی عنوان
تحریک عصب واگ در کودکان کمتر از 3 سال مبتلا به صرع مقاوم در معرض پزشکی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• We describe the characteristics of 15 children younger than 3 years of age at the time of VNS implant.
• Normal MRI was associated with seizure improvement at one year.
• The frequency of generalized convulsive seizure and status epilepticus decreased.
• Complication was seen in 2/15 (13%) patients, or in 2/21 (9.5%) procedures.

ObjectiveTo describe the characteristics of children less than three years of age with medically intractable epilepsy, who underwent Vagus Nerve Stimulator (VNS) therapy at Children's Hospital of Pittsburgh between 2004 and 2011. Methods: Retrospective chart review. Results: Seventeen patients were identified; adequate follow-up was available for 15. Median follow up duration was 4.3 years (1.4–10.2 years). 12/15 (80%) had a known etiology for their epilepsy. All patients had more than 1 seizure per week prior to VNS and a history of status epilepticus was frequent (40%, 6/15). Five patients (33%) reported improved seizure frequency at one year after VNS. A normal MRI was associated with seizure improvement (p = 0.007). No patient had status epilepticus after VNS at one-year follow-up. At three years after VNS, four patients had experienced status epilepticus with only one patient experiencing multiple episodes. Complications were seen in 2/15 (13%) patients and in 2/21 (9.5%) procedures. Significance: A normal MRI was associated with seizure improvement at one year in children less than three years of age at the time of VNS implant. The degree of overall seizure reduction was modest, but the frequency of status epilepticus was decreased after VNS implant. VNS was tolerated well in this age group.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 112, May 2015, Pages 37–42
نویسندگان
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