کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3052094 1579918 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats
چکیده انگلیسی

SummaryA role of cholinergic nervous system in the behavioral impairments induced by repeated ECS is not understood. The α4β2 nicotinic acetylcholine receptor (nAChR) agonist ABT-418, but not the α7 nAChR agonist, significantly ameliorated the impairment of spontaneous alternation behavior in the Y-maze test. And, repeated ECS caused a reduction of α4 nAChR-positive cells in the prefrontal cortex and hippocampus. Thus, the α4β2 nAChR is related to ECS-induced deficits in rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 104, Issues 1–2, March 2013, Pages 181–185
نویسندگان
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