GABBR1 gene polymorphism(G1465A)isassociated with temporal lobe epilepsy

SummaryPurposeγ-Aminobutyric acid B receptor 1(GABBR1) gene G1465A polymorphism has been considered as a potential risk factor for the development of temporal lobe epilepsy (TLE). However, the results were inconsistent. In this study, we performed a meta-analysis to assess the association between GABBR1 G1465A polymorphism and the risk of TLE.MethodsBiomedical literature databases including PubMed, ISI web of science and Embase were searched. The studies evaluating the association between GABBR1 G1465A polymorphism and TLE were included. Pooled odds ratio (OR) and 95%CI confidence interval (CI) were calculated using fixed- or random-effects model.Key findingsSeven studies (1011 cases and 2184 controls) met the inclusion criteria and were included in the meta-analysis. The overall result showed that the association between GABBR1 G1465A polymorphism was statistically significant (OR = 5.381, 95%CI: 1.726, 16.776, P = 0.004). Subgroup analysis showed that the effect estimate was higher in the studies with high quality score (OR = 14.220, 95%CI: 6.933, 29.169, P = 0.000) than that in the studies with low quality score (OR = 1.158, 95%CI: 0.325, 4.123, P = 0.821).SignificanceThe present meta-analysis suggests that GABBR1 G1465A polymorphism is associated with the risk of TLE. The role of GABBR1 G1465A polymorphism in the development of TLE merits further investigation.