کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3053045 | 1579949 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Intra-amygdala all-trans retinoic acid inhibits amygdala-kindled seizures in rats Intra-amygdala all-trans retinoic acid inhibits amygdala-kindled seizures in rats](/preview/png/3053045.png)
SummaryAmygdala plays an important role in induction and control of limbic seizures. There is a network of gap junctional communications in basolateral amygdala (BLA) as well. We compared the effect of intra-BLA infusion of the typical gap junction (GJ) blocker carbenoxolone (CBX), with the effect of putative GJ blocker all-trans retinoic acid (ATRA), on the afterdischarge (AD) recorded from BLA in amygdala-kindled rats. Both CBX and ATRA showed a rapid anti-seizure effect. Conversely, intra-BLA infusion of the known GJ opener, trimethylamine (TMA), enhanced seizure susceptibility by prolonging the duration of AD and generalized behavioral seizures. ATRA administered intra-BLA prevented the proconvulsant effect of TMA. The reduction of gap junctional conductance might be involved in the observed anticonvulsant effect of ATRA.
Journal: Epilepsy Research - Volume 75, Issues 2–3, July 2007, Pages 97–103