کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3054264 1580031 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
First long-term experience with the orphan drug rufinamide in children with myoclonic-astatic epilepsy (Doose syndrome)
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
First long-term experience with the orphan drug rufinamide in children with myoclonic-astatic epilepsy (Doose syndrome)
چکیده انگلیسی

IntroductionWe evaluated the long-term efficacy and tolerability of the orphan drug rufinamide (RUF) in children with pharmacoresistant myoclonic-astatic epilepsy (MAE, Doose syndrome).MethodsThis was a retrospective European multicenter study on eight patients who had started an intention-to-treat trial of RUF between July 2007 and June 2010. Clinical information was collected via questionnaire. Responder rate was defined as reduction of seizure frequency ≥50% in comparison to four weeks before starting RUF. Maximum follow-up was eighteen months.ResultsResponder rates were 7/8 patients after 3 months, 6/8 patients after 6 months and 5/8 patients after 12 months. RUF seemed particularly effective in the prevention of myoclonic-astatic seizures (comparable with drop attacks in Lennox-Gastaut-Syndrome, for which RUF is particularly effective). Some loss of efficacy was noticed in the long-term observation. Side-effects occurred in two patients. Seizure aggravation was not observed.ConclusionRUF seems to be a promising therapeutic option in children with MAE. Further studies are warranted to confirm these first observations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Paediatric Neurology - Volume 16, Issue 5, September 2012, Pages 459–463
نویسندگان
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