کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3058185 1187402 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In-hospital outcomes of thrombolysis for acute ischemic stroke in patients with primary brain tumors
ترجمه فارسی عنوان
نتایج درمانی بیماران مبتلا به سکته مغزی حاد سکته مغزی در بیماران مبتلا به تومورهای مغزی اولیه
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

Data on thrombolysis outcomes in patients with primary brain tumors are limited. Our aim was to study stroke outcomes following thrombolysis in these patients in a population-based study. Patients with acute ischemic stroke who received thrombolysis were identified from the 2002–2011 USA Nationwide Inpatient Sample. We compared demographics, comorbidities, and outcomes between primary brain tumor-associated strokes (BTS) and non-brain tumor associated strokes (NBTS). The main outcomes were inpatient mortality, home discharge and intracranial hemorrhage (ICH) rate. Of the 124,083 thrombolysis-treated stroke patients, 416 (0.34%) had brain tumors. In adjusted analysis, inpatient mortality (odds ratio [OR]: 0.98; 95% confidence interval [CI]: 0.77–1.26, p = 0.918), rate of home discharge (OR: 1.15; 95% CI: 0.87–1.53, p = 0.40) and rate of ICH (OR: 0.94; 95% CI: 0.62–1.44, p = 0.801) were similar between BTS and NBTS. Analysis of brain tumor subtypes showed that compared to NBTS, malignant BTS were independently associated with higher in-hospital mortality (OR: 2.51; 95% CI: 1.66–3.79, p < 0.001), lower home discharge (OR: 0.36, 95% CI: 0.18–0.72, p = 0.004), and increased risk of ICH (OR: 2.33, 95% CI: 1.49–3.65, p < 0.001). Additionally, among the BTS, intraparenchymal location of tumor was associated with higher mortality (OR: 2.51; 95% CI: 1.20–5.23, p = 0.014) and lower home discharge (OR: 0.26; 95% CI: 0.13–0.53, p < 0.001). Thrombolytic therapy for acute stroke appears to be safe in patients with primary brain tumors, with similar rates of ICH. Malignant BTS have worse outcomes, while benign BTS have outcomes comparable to NBTS. Careful consideration of tumor pathology may aid selection of patients with poor thrombolysis outcomes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 22, Issue 3, March 2015, Pages 474–478
نویسندگان
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