کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3058807 1187414 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Deep brain stimulation for chronic pain
ترجمه فارسی عنوان
تحریک مغزی عمیق برای درد مزمن
کلمات کلیدی
قشر مفاصل قدامی قدامی درد مزمن، تحریک مغزی عمیق، خاکستری پرآبی خاکستری پریوژنتیک تالاموس حسی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• Deep brain stimulation is an effective therapy for patients with intractable pain.
• The common targets are periaqueductal/periventricular gray (PAG/PVG) and sensory thalamus (VPL/VPM).
• The affective component of pain can now be targeted.

Deep brain stimulation (DBS) is a neurosurgical intervention popularised in movement disorders such as Parkinson’s disease, and also reported to improve symptoms of epilepsy, Tourette’s syndrome, obsessive compulsive disorders and cluster headache. Since the 1950s, DBS has been used as a treatment to relieve intractable pain of several aetiologies including post stroke pain, phantom limb pain, facial pain and brachial plexus avulsion. Several patient series have shown benefits in stimulating various brain areas, including the sensory thalamus (ventral posterior lateral and medial), the periaqueductal and periventricular grey, or, more recently, the anterior cingulate cortex. However, this technique remains “off label” in the USA as it does not have Federal Drug Administration approval. Consequently, only a small number of surgeons report DBS for pain using current technology and techniques and few regions approve it. Randomised, blinded and controlled clinical trials that may use novel trial methodologies are desirable to evaluate the efficacy of DBS in patients who are refractory to other therapies. New imaging techniques, including tractography, may help optimise electrode placement and clinical outcome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 22, Issue 10, October 2015, Pages 1537–1543
نویسندگان
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