کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3059387 1187426 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased premotor cortex activation in high functioning autism during action observation
ترجمه فارسی عنوان
افزایش فعالیت قشر پرموتور در اوتیسم با عملکرد بالا در طی مشاهده فعالیت
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

The mirror neuron (MN) hypothesis of autism has received considerable attention, but to date has produced inconsistent findings. Using functional MRI, participants with high functioning autism or Asperger’s syndrome were compared to typically developing individuals (n = 12 in each group). Participants passively observed hand gestures that included waving, pointing, and grasping. Concerning the MN network, both groups activated similar regions including prefrontal, inferior parietal and superior temporal regions, with the autism group demonstrating significantly greater activation in the dorsal premotor cortex. Concerning other regions, participants with autism demonstrated increased activity in the anterior cingulate and medial frontal gyrus, and reduced activation in calcarine, cuneus, and middle temporal gyrus. These results suggest that during observation of hand gestures, frontal cortex activation is affected in autism, which we suggest may be linked to abnormal functioning of the MN system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 22, Issue 4, April 2015, Pages 664–669
نویسندگان
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