کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3059392 1187426 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of prognostic factors and treatment of anaplastic meningioma in China
ترجمه فارسی عنوان
تجزیه و تحلیل عوامل پیش آگهی و درمان مننژیمای آناپلاستیک در چین
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

Meningioma is the most frequently reported primary brain and central nervous system tumor. However, malignant meningioma is rare with the anaplastic subtype the most common. This subtype of meningioma is fatal with a high recurrence rate and poor survival. A retrospective review of anaplastic meningioma patients treated in one of the largest neurosurgical centers in China between 2003 and 2008 was conducted. From 70 identified patients, seven were lost to follow-up, but the remaining 63 patients were studied for prognostic factors. The mean follow-up time was 84.9 ± standard deviation (SD) of 19.7 months. Tumor recurred in 35 out of 63 (55.6%) patients. Thirty-three (52.4%) patients had died by the most recent follow-up, and the median overall survival (OS) was 70.0 ± 9.7 months. The 3 year and 5 year survival rates were 68.3% and 54.7%, respectively. The median progression-free survival (PFS) was 52.0 ± 9.9 months, whereas the 3 year and 5 year PFS rates were 60.2% and 43.9%, respectively. We found that preoperative KPS, extent of tumor resection, radiotherapy, tumor location and previous history of meningioma were factors related to PFS. In the non-recurrent group, the preoperative Karnofsky Performance Scale (KPS), extent of tumor resection and radiotherapy correlated with PFS. However, multivariate analysis identified radiotherapy as the only independent factor affecting PFS (p = 0.007). Additionally, MIB-1 proliferation index failed to identify a cut-off point to predict the prognosis for anaplastic meningioma. This study provides an overview of the epidemiology and treatment of anaplastic meningioma in China using a large population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 22, Issue 4, April 2015, Pages 690–695
نویسندگان
, , , , , , , , , , , , , , , ,