کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3059481 1187428 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tumour associated epilepsy and glutamate excitotoxicity in patients with gliomas
ترجمه فارسی عنوان
در بیماران مبتلا به گلیوما، صرع مربوط به تومور و سمیت اکسی توسین گلوتامات
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

Tumour associated epilepsy (TAE) is common, debilitating and often not successfully controlled by surgical resection of the tumour and administration of multiple anti-epileptic drugs. It represents a cause of significant lost quality of life in an incurable disease and is therefore an important subject for ongoing research. The pathogenesis of TAE is likely to be multifactorial and involve, on the microscopic level, the interaction of genetic factors, changes in the peritumoural microenvironment, alterations in synaptic neurotransmitter release and re-uptake, and the excitotoxic effects of glutamate. On a macroscopic level, the occurrence of TAE is likely to be influenced by tumour size, location and interaction with environmental factors. The optimal treatment of TAE requires a multi-disciplinary approach with input from neurosurgeons, neurologists, radiologists, pathologists and basic scientists. This article reviews the current literature regarding the incidence, treatment, and aetiology of TAE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 21, Issue 6, June 2014, Pages 899–908
نویسندگان
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