کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3061031 1187462 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physical and functional cooperation of neural cell adhesion molecule and β1-integrin in neurite outgrowth induction
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Physical and functional cooperation of neural cell adhesion molecule and β1-integrin in neurite outgrowth induction
چکیده انگلیسی

Neural cell adhesion molecule (NCAM) and β1-integrin are both involved in cell differentiation, with changes in the expression of these two molecules correlating with changes in the malignancy of tumor cells. There is a known functional correlation between NCAM and β1-integrin in adhesion and also neurite outgrowth in tumor cells. In the present study, we used immunostaining and immunoprecipitation studies to demonstrate that isoform 120 of NCAM associates physically as well as functionally with β1-integrin in the induction of neurite outgrowth in SH-SY5Y-human neuroblastoma cells. The interaction between these two molecules is mandatory for neurite outgrowth. NCAM blockage completely inhibits the effects of β1-integrin on neurite outgrowth. These findings further our understanding of the interactions between NCAMs and integrins in malignancy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 18, Issue 8, August 2011, Pages 1109–1113
نویسندگان
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