کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3061738 | 1187478 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gamma knife radiosurgery for growth hormone-producing adenomas
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
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چکیده انگلیسی
We evaluated the endocrinological outcomes of gamma knife radiosurgery (GKS) for the treatment of growth hormone (GH)-producing pituitary adenomas. Twenty-six patients treated with GKS (median treatment [tumour] volume: 0.8 mL; median marginal radiation dose: 20 Gy) were followed for a median of 84 months. “Disease remission” was defined as either nadir levels of GH <1 μg/L during an oral glucose load, or random GH levels <2 μg/L and normal age-adjusted and sex-adjusted levels of insulin-like growth factor without pituitary suppressive medications. The remission rate was 38% (10/26) and the 5-year and 10-year actuarial remission rates were 16.9% and 47.4%, respectively. Two patients (8%) suffered hypopituitarism requiring medication, but no other serious deficits were observed. Although GKS requires a relatively long time to achieve hormonal remission, it is a very useful, long-term treatment for GH-producing adenomas. We propose that compared to continuing life-long medication, GKS is less invasive and more cost effective.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 17, Issue 3, March 2010, Pages 299-304
Journal: Journal of Clinical Neuroscience - Volume 17, Issue 3, March 2010, Pages 299-304
نویسندگان
Yoshiyasu Iwai, Kazuhiro Yamanaka, Masaki Yoshimura, Isao Kawasaki, Keiko Yamagami, Katsunobu Yoshioka,