Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis

• Glial and neuronal markers were analysed in 324 CSF samples of different types of MS.
• Neurofilament concentrations were higher in relapsing forms of MS.
• Glial fibrillary acidic protein concentrations were higher in progressive forms of MS.
• CSF concentrations of NFL and YKL-40 correlated in CIS and RRMS patients.
• CSF concentrations of GFAP and YKL-40 correlated in relapsing-remitting patients.

In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, α-sAPP, β-sAPP, and Aβ38, Aβ40, Aβ42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients.

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