کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3063815 1580377 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuron-astrocyte interactions in spinal cord dorsal horn in neuropathic pain development and docosahexaenoic acid therapy
ترجمه فارسی عنوان
تعامل نورون-آستروسیت در شاخ پشتی نخاعی در توسعه درد نوروپاتیک و درمان اسکواشاهنائوئیک اسید
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


• DHA reduced the intensity and duration of neuropathic pain.
• Also it stabilized weight bearing, prevented the development of cold allodynia.
• DHA treatment reduced reactive astrocyte in spinal cord of neuropathic pain rats.
• This drug decreases the activity of SP-immunopositive fibers and nNOS-positive neurons in the SCDH.

The analgesic activity of docosahexaenoic acid (DHA, 22:6 n − 3) was studied using a chronic constriction injury (CCI) rat model. Animals were subcutaneously injected with DHA emulsion at a dose of 4.5 mg/kg (125 mМ/kg) daily during 2 weeks after surgery. We characterized the dynamics of GFAP-positive astrocyte, substance P (SP) and nNOS-positive neurons activity in the spinal cord dorsal horn (SCDH) superficial lamina. We found that DHA treatment decrease the intensity and duration of neurogenic pain syndrome, results in earlier stabilization of weight distribution, prevents the cold allodynia and dystrophic changings in denervated limb tissue. DHA treatment reduced the reactive astrocyte number, decrease SP-immunopositive fibers and nNOS-positive neurons number in the SCDH in neuropathic pain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 298, 15 September 2016, Pages 90–97
نویسندگان
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