Increased expression of interleukin 17 in the cortex and hippocampus from patients with mesial temporal lobe epilepsy

• IL-17 and IL-17R were upregulated in MTLE at both mRNA and protein levels.
• IL-17 was specifically distributed in neurons, glia and endothelial cells.
• IL-17 may be involved in the pathogenesis and epileptogenicity of MTLE.

Mesial temporal lobe epilepsy (MTLE) is the most common form of focal epilepsies in adults and proinflammatory cytokines have long been thought to play an important role in pathogenesis and epileptogenicity. In the present study, we investigated the levels and expression patterns of the interleukin 17 (IL-17) system in temporal neocortex and hippocampus from 24 patients with MTLE and 8 control (Ctr) samples. We found that IL-17 and IL-17 receptor (IL-17R) were clearly upregulated in MTLE at both mRNA and protein levels, compared with Ctr. Immunostaining indicated that neurons, astrocytes, microglia and endothelial cells of blood vessels are the major sources of IL-17. These findings suggest that IL-17 system may be involved in the pathogenesis and epileptogenicity of MTLE.

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