Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model

• LA significantly reduces inflammation in a focal cortical model of MS.
• Monocytes are significantly reduced around the lesion area
• This study provides a rationale for investigating the ability of LA to reduce development of cortical lesions in MS.

Cortical lesions are a crucial part of MS pathology and it is critical to determine that new MS therapies have the ability to alter cortical inflammatory lesions given the differences between white and gray matter lesions. We tested lipoic acid (LA) in a mouse focal cortical EAE model. Brain sections were stained with antibodies against CD4, CD11b and galectin-3. Compared with vehicle, treatment with LA significantly decreased CD4 + and galectin-3 + immune cells in the brain. LA treated mice had fewer galectin-3 + cells with no projections indicating decrease in the number of infiltrating monocytes. LA significantly reduces inflammation in a focal cortical model of MS.

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