Total glucosides of peony attenuates experimental autoimmune encephalomyelitis in C57BL/6 mice

• TGP can reduce the severity of EAE in C57 BL/6 mice.
• TGP down-regulated the Th1/Th17 inflammatory response of EAE.
• TGP prevented the reduced expression of BDNF and CNPase of EAE.
• TGP could be a potential therapeutic agent for multiple sclerosis.

Total glucosides of peony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pall, has wide pharmacological effects on nervous system. Here we examined the effects of TGP on experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). The results showed that TGP can reduce the severity and progression of EAE in C57 BL/6 mice. In addition, TGP also down-regulated the Th1/Th17 inflammatory response and prevented the reduced expression of brain-derived neurotrophic factor and 2′,3′-cyclic nucleotide 3′-phosphodiesterase of EAE. These findings suggest that TGP could be a potential therapeutic agent for MS.