کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064041 | 1580405 | 2014 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: SVα-MSH, a novel α-melanocyte stimulating hormone analog, ameliorates autoimmune encephalomyelitis through inhibiting autoreactive CD4+ T cells activation SVα-MSH, a novel α-melanocyte stimulating hormone analog, ameliorates autoimmune encephalomyelitis through inhibiting autoreactive CD4+ T cells activation](/preview/png/3064041.png)
• SVα-MSH, a novel α-MSH analog, acts as a novel immunotherapeutic approach for EAE.
• SVα-MSH treatment induced Treg cells production and reduced Th17 cells in EAE mice.
• SVα-MSH down-regulates T cell activation markers CD69 and CD134 on TPLP139–151 cells.
• SVα-MSH did not induce apoptosis but blocked the G1/S phase transition.
• SVα-MSH reduced cyclin E, Cdk2 expression and the activity of NFAT and AP-1.
Alpha-melanocyte stimulating hormone (α-MSH) plays a crucial role in the regulation of immune and inflammatory reactions. Here we report that SVα-MSH, a novel α-MSH analog, could ameliorate the clinical severity of experimental autoimmune encephalomyelitis (EAE) in a preventive and therapeutic manner. SVα-MSH treatment induced the production of regulatory T (Treg) cells and reduced the Th17 cells in the CNS of EAE mice. SVα-MSH-treated PLP peptide 139–151-specific T cells showed a down-regulation of T cell activation markers CD69 and CD134. SVα-MSH did not induce apoptosis but blocked the G1/S phase transition, reduced the expression of cyclin E, Cdk2 and the activity of NFAT and AP-1 transcription factors. Thus, SVα-MSH acts as a novel immunotherapeutic approach in the treatment of autoimmune attack on the CNS.
Journal: Journal of Neuroimmunology - Volume 269, Issues 1–2, 15 April 2014, Pages 9–19