کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064268 | 1580414 | 2013 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: CD8+ T cell help is required for efficient induction of EAE in Lewis rats CD8+ T cell help is required for efficient induction of EAE in Lewis rats](/preview/png/3064268.png)
• We investigated the role of CD8+ T cells in the EAE of the Lewis rat.
• Complete depletion or genetic ablation of CD8+ T cells protects Lewis rats from EAE.
• Reduced infiltration of leukocytes into the CNS in the absence of CD8+ T cells
• CD8-deficiency interferes with the generation of encephalitogenic CD4+ T cells.
The role of CD8+ T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats depleted of CD8+ T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD4+ T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-γ-producing effector cells. Our results indicate that CD8+ T cells interact with myelin-specific CD4+ T cells early in EAE enabling them to differentiate into pathogenic effector cells.
Journal: Journal of Neuroimmunology - Volume 260, Issues 1–2, 15 July 2013, Pages 17–27