کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064298 1580418 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intravenous immunoglobulin inhibits BAFF production in chronic inflammatory demyelinating polyneuropathy — A new mechanism of action?
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Intravenous immunoglobulin inhibits BAFF production in chronic inflammatory demyelinating polyneuropathy — A new mechanism of action?
چکیده انگلیسی

Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disease treated with intravenous immunoglobulin (IVIg). The underlying mechanism of action remains incompletely understood.The B-cell activating factor BAFF contributes to B-cell homeostasis and (auto-)antibody production. BAFF was recently identified as one key molecule in the development of autoimmune diseases.Herein, we demonstrate that BAFF serum levels are elevated in CIDP patients. IVIg treatment resulted in a significant decrease of BAFF serum level. In vitro, IVIg inhibited BAFF in monocytes.Consequently, we identified BAFF as a new target for IVIg in CIDP treatment and provide a new, Fcγ-receptor independent, mechanism of action for IVIg.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 256, Issues 1–2, 15 March 2013, Pages 84–90
نویسندگان
, , , , , , , , ,