کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064317 1580431 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Frequency and function of regulatory T cells after ischaemic stroke in humans
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Frequency and function of regulatory T cells after ischaemic stroke in humans
چکیده انگلیسی

Ischaemic stroke is an important cause of disability and death. Local inflammation in the brain following stroke is thought to enhance damage. Animal studies show that regulatory T cells (Tregs) can downregulate this inflammation and assist recovery, but there are no previous studies of the function of Tregs in human stroke. The current study aimed to quantify Tregs in peripheral blood following stroke and to investigate their function. Treg numbers were significantly increased after stroke, particularly in males. However, the functional capacity of Tregs to inhibit proliferation of autologous cells at low ratios of Treg to responder cells was reduced, particularly in female patients, compared to controls. This study is the first to report gender-specific changes in the numbers and function of Tregs after ischaemic stroke. These changes may affect stroke outcome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 243, Issues 1–2, 29 February 2012, Pages 89–94
نویسندگان
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