کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064412 | 1580438 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes](/preview/png/3064412.png)
چکیده انگلیسی
A locus on mouse chromosome 16 was found to control experimental autoimmune encephalomyelitis (EAE) in studies using congenic mice. Genes within the congenic region control encephalomyelitis but not arthritis, indicating the presence of genes in this region involved in central nervous system (CNS) specific mechanisms. Flow cytometry analyses of expression of two candidate genes within the linked locus, Cd200 and Btla, demonstrated a significantly lower expression of CD200 on CD4+ T cells and higher expression of BTLA on B cells from the congenic mice. These results suggest that genes within this mouse chromosome 16 locus specifically control EAE development possibly through immune-regulatory cell-surface molecules.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 235, Issues 1–2, June 2011, Pages 40–47
Journal: Journal of Neuroimmunology - Volume 235, Issues 1–2, June 2011, Pages 40–47
نویسندگان
Therese Lindvall, Kutty Selva Nandakumar, Kimia Yousefi, Rikard Holmdahl, Åsa Andersson,