کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064416 1580438 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recombination mapping of the susceptibility region for sporadic inclusion body myositis within the major histocompatibility complex
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Recombination mapping of the susceptibility region for sporadic inclusion body myositis within the major histocompatibility complex
چکیده انگلیسی

Susceptibility to sporadic inclusion body myositis (sIBM) in Caucasians has been consistently associated with alleles of the major histocompatibility complex (MHC) 8.1 ancestral haplotype (AH) (defined by HLA-B*0801 and HLA-DRB1*0301). In this study recombination mapping was utilised to further refine the known 8.1AH susceptibility region near HLA-DRB1*0301. Caucasian sIBM patients carrying part of the 8.1AH were genotyped for a selection of 8.1AH-haplotypic polymorphisms. A common 8.1AH-specific susceptibility region was defined, spanning 172 kb and encompassing three genes — HLA-DRB3, HLA-DRA and BTNL2. It is thus likely that 8.1AH-derived susceptibility to sIBM originates from at least one of these genes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 235, Issues 1–2, June 2011, Pages 77–83
نویسندگان
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