کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064432 | 1580434 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of fasudil on the permeability of the rat blood–brain barrier and blood–spinal cord barrier following experimental autoimmune encephalomyelitis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The effects of fasudil on the permeability of the rat blood–brain barrier and blood–spinal cord barrier following experimental autoimmune encephalomyelitis The effects of fasudil on the permeability of the rat blood–brain barrier and blood–spinal cord barrier following experimental autoimmune encephalomyelitis](/preview/png/3064432.png)
چکیده انگلیسی
Dysfunction of the blood–brain barrier (BBB) and blood–spinal cord barrier (BSCB) is a primary characteristic of multiple sclerosis (MS). We evaluated the protective effects of fasudil, a selective ROCK inhibitor, in a model of experimental autoimmune encephalomyelitis (EAE) that was induced by guinea-pig spinal cord. In addition, we studied the effects of fasudil on BBB and BSCB permeability. We found that fasudil partly alleviated EAE-dependent damage by decreasing BBB and BSCB permeability. These results provide rationale for the development of selective inhibitors of Rho kinase as a novel therapy for MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 239, Issues 1–2, 28 October 2011, Pages 61–67
Journal: Journal of Neuroimmunology - Volume 239, Issues 1–2, 28 October 2011, Pages 61–67
نویسندگان
X.N. Huang, J. Fu, W.Z. Wang,