کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064459 | 1580443 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HLA polymorphisms in Italian children with autism spectrum disorders: Results of a family based linkage study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: HLA polymorphisms in Italian children with autism spectrum disorders: Results of a family based linkage study HLA polymorphisms in Italian children with autism spectrum disorders: Results of a family based linkage study](/preview/png/3064459.png)
چکیده انگلیسی
To verify correlations between HLA and autism spectrum disorders (ASD) we studied 61 Italian families with an ASD child; results showed such correlation in 65% of cases. Case–control and TDT analysis of intrafamilial transmission of SNPs, Msats, and HLA markers surrounding the α and β blocks, indicated significant positive associations for MOGc*131 and D6S2239*105 alleles in ASD, and a negative association of MIB *332 allele in healthy siblings. Polymorphism haplotype analysis demonstrated that two haplotypes comprising the TNF-238(G)-TNF-308(G)-MIB*332-HLA-B*38-HLA-Cw*12 and the D6S265*218-HLA-A*23-MOGc*131-rs2857766(G) alleles are more frequently transmitted to ASD. MOGc and MIB loci are linked with ASD in Italian patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 230, Issues 1–2, January 2011, Pages 135–142
Journal: Journal of Neuroimmunology - Volume 230, Issues 1–2, January 2011, Pages 135–142
نویسندگان
Franca R. Guerini, Elisabetta Bolognesi, Matteo Chiappedi, Annalisa De Silvestri, Alessandro Ghezzo, Michela Zanette, Beatrice Rusconi, Salvatorica Manca, Stefano Sotgiu, Cristina Agliardi, Mario Clerici,