کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064575 1580442 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical and biological heterogeneity of autoimmune myasthenia gravis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Clinical and biological heterogeneity of autoimmune myasthenia gravis
چکیده انگلیسی

Although myasthenia gravis (MG) has long been considered a well-established autoimmune disease associated with autoantibodies, which are convincingly pathogenic, accumulating data indicate both clinical and biological heterogeneity similar to many other putative autoimmune disorders. In a subset of patients, thymus plays a definite role: thymic autoimmunity results in generation of autoantibodies within the thymus, which cross-react with antigens at the neuromuscular junction, or thymoma leads to deficient central tolerance and impaired T cell selection. Heterogeneity on the autoantibody level may be associated with genetic heterogeneity and clinical phenotypes with different treatment responses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 231, Issues 1–2, February 2011, Pages 43–54
نویسندگان
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