کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064601 | 1580452 | 2010 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells](/preview/png/3064601.png)
The expression of major histocompatibility complex (MHC) on human neural stem cells (hNSCs) is tightly related to the fate of these cells in transplantation, therefore strategies to relieve rejection and promote graft survival are necessary to be applied. This study investigated the effect of carbamylated erythropoietin (CEPO) on MHC expression and differentiation of hNSCs with or without IFN-γ incubation. Results showed that low levels of MHC molecules were expressed on hNSCs and increased by IFN-γ. CEPO enhanced MHC-I antigens in both proliferative and differentiated hNSCs, but decreased MHC-II antigens in differentiated hNSCs and those cells exposed to IFN-γ. Furthermore, CEPO promoted neural differentiation of hNSCs and outgrowth of neurites. Western blot analysis revealed activation of Stat3, Stat5 and Akt during these processes. These results suggest that CEPO may have immunoregulatory function in hNSCs besides its neuroprotection.
Journal: Journal of Neuroimmunology - Volume 221, Issues 1–2, 15 April 2010, Pages 15–24