کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064608 1580452 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential expression of aquaporin-4 isoforms localizes with neuromyelitis optica disease activity
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Differential expression of aquaporin-4 isoforms localizes with neuromyelitis optica disease activity
چکیده انگلیسی

Neuromyelitis optica (NMO) is a devastating neuroinflammatory disorder that specifically targets the spinal cord and optic nerves. Aquaporin-4 (AQP4) is the target of the NMO-IgG biomarker. AQP4 is expressed as two isoforms: M1 and M23, which have different functions in the central nervous system (CNS). We characterized the expression pattern of these AQP4 isoform mRNAs in humans and found a pattern of AQP4 expression that correlates with NMO disease localization. The ratio of M1:M23 mRNA is highest in the optic nerve and spinal cord, followed by brainstem, then the cerebral and cerebellar cortices.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 221, Issues 1–2, 15 April 2010, Pages 68–72
نویسندگان
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