کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064638 1580449 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases
چکیده انگلیسی

Inflammatory response represents one of the first immune processes following injury. It is characterized by the production of various molecules that initiate the recruitment of immune cells to the lesion sites, including in the brain. Accordingly, in acute brain trauma, such as stroke, as well as during chronic affections like multiple sclerosis or Alzheimer’s disease, inflammation occurs in order to “clean up” the lesion and to limit its area. Nevertheless, prolonged and sustained inflammation may have cytotoxic effects, aggravating the incidence and the severity of the disease. Among molecules produced during inflammation associated to neuronal death, monocyte chemoattractant proteins (MCPs) seem to be particularly important. This review will focus on the current knowledge about one of the MCPs, CCL2, and its cognate receptor, CCR2, both expressed in physiological conditions and during neurodegenerative diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 224, Issues 1–2, 27 July 2010, Pages 93–100
نویسندگان
, , , , ,