کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064665 1580447 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The risk of relapse after a clinically isolated syndrome is related to the pattern of oligoclonal bands
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The risk of relapse after a clinically isolated syndrome is related to the pattern of oligoclonal bands
چکیده انگلیسی
We prospectively assessed the risk of second relapse in 192 patients with clinically isolated syndromes (CIS) divided into three groups: patients lacking oligoclonal IgG bands (OC-IgG, 25.7%), those showing OC-IgG (52.4%), and those with both OC-IgG and lipid-specific IgM bands (LS-OC-IgM, 22%). OC-IgG increased 9.3-fold the risk compared to lacking OC-IgG; OC-IgG + LS-OC-IgM increased the risk 39.6-fold compared to not having OC-IgG and 4.4-fold compared to having only OC-IgG. Median time to second relapse was 0.7 years for patients with OC-IgG + LS-OC-IgM and 3.3 years for those with only OC-IgG. Therefore, CSF analysis identifies CIS patients at risk of second relapse.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 226, Issues 1–2, 14 September 2010, Pages 143-146
نویسندگان
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