کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064667 | 1580447 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pro-inflammatory cytokine and chemokine mRNA blood level in multiple sclerosis is related to treatment response and interferon-beta dose
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Of 37 multiple sclerosis patients, 19 suboptimal responders were randomized to 375 (n = 12) or 250 µg (n = 7) interferon (IFN)-β-1b. mRNA levels of 23 cytokines, chemokines, and chemokine receptors were quantified by TaqMan® low-density array (TLDA) real-time polymerase chain reaction. Better treatment responses or increased IFN-β doses were associated with elevated IL-10 and TGF-β and decreased CXCL10, IL-18, IFN-γ, and TNF-α transcript levels. Adjusting for dose, poor treatment responses resulted in a 4-fold increase in CXCL10 and IFN-γ expression (Mantel-Haenszel RR = 3.74, p < 0.0001). CXCL10 and IFN-γ mRNA levels were reliable indicators of treatment response. TLDA can be used to tailor IFN-β-1b therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 226, Issues 1–2, 14 September 2010, Pages 150–157
Journal: Journal of Neuroimmunology - Volume 226, Issues 1–2, 14 September 2010, Pages 150–157
نویسندگان
Angele Cucci, Pierangelo Barbero, Marinella Clerico, Bruno Ferrero, Elisabetta Versino, Giulia Contessa, Stefania Demercanti, Emanuela Viglietta, Alessandra Di Liberto, Alessandra Giai Vai, Luca Durelli,