کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064695 1580453 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MGAT5 alters the severity of multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
MGAT5 alters the severity of multiple sclerosis
چکیده انگلیسی

Multiple Sclerosis (MS) is a genetically complex immune mediated, demyelinating disease of the central nervous system. To date no genetic variants have been unambiguously linked to disease severity. We have conducted a genome wide screen, using Affymetrix Genechip® 500K technology, for severity in 1040 MS patients. Two markers within MGAT5, a gene coding for a glycosylation enzyme, were found to be significantly associated with outcome in the screening as well as in an independent population (combined p-values: 2.8 × 10− 6 and 1.5 × 10− 7).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 220, Issues 1–2, 30 March 2010, Pages 120–124
نویسندگان
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