کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3064723 1580450 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells
چکیده انگلیسی

It has been recently shown that systemically injected neural precursor cells (NPCs) could cross brain endothelium and favor functional recovery in animal models of multiple sclerosis (MS). Here we show that human NPCs express receptors of the chemokines IL8 and CXCL13 (CXCR1 and CXCR5, respectively) and migrate across brain endothelial cells in vitro, in response to these chemokines. Considering that these chemokines have been found overexpressed in MS in active, but not inactive areas of demyelination, our data suggest that systemically injected human NPCs may be considered for targeting active areas of demyelination in therapeutic approaches of MS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 223, Issues 1–2, June 2010, Pages 131–134
نویسندگان
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