کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065005 1580459 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy
چکیده انگلیسی

We investigated potential therapeutic effects of sphingosine-1-phosphate (S1P) receptor modulators FTY720 (fingolimod) and selective S1P1 agonist SEW2871 on a spontaneous autoimmune polyneuropathy (SAP) when given orally at 7 mo (anticipated disease onset) for 4 weeks. Clinical severity, electrophysiologic and histological findings were ameliorated in mice treated with 1 mg/kg of FTY720. Subsequent studies showed that SEW2871 was also effective in halting the progression of SAP, which was accompanied by decreased proliferative and cytokine responses to myelin protein zero (P0), and an increase in regulatory T cells. We conclude that S1P receptor modulators may play a therapeutic role in autoimmune neuropathies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 214, Issues 1–2, 29 September 2009, Pages 93–100
نویسندگان
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