کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065080 1580461 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased rat serum corticosterone suggests immunomodulation by stimulation of the vagal nerve
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Increased rat serum corticosterone suggests immunomodulation by stimulation of the vagal nerve
چکیده انگلیسی

The role of the vagal nerve within the immune system has not been fully elucidated. Vagal afferents connect to several central nervous system structures, including the hypothalamus. We investigated the effect of vagal nerve stimulation (VNS) on serum corticosterone levels in rats. Corticosterone levels were measured following 1 h of high frequency (30 Hz) or low frequency (1 Hz) VNS in awake animals. There was a significant increase (p < 0.05) in serum corticosterone levels following 30 Hz VNS compared to 1 Hz VNS or sham stimulation. These results suggest an immediate effect of VNS on the hypothalamic pituitary-adrenal (HPA) axis and support the role of the vagal nerve in immunomodulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 212, Issues 1–2, 25 July 2009, Pages 102–105
نویسندگان
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