کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065118 | 1580468 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CSF neurofilament and soluble TNF receptor 1 levels in subacute sclerosing panencephalitis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Neurofilament (NF) is one of the major cytoskeleton proteins of neurons and sTNFR1 is thought to reflect the true biological activity of TNF-α. To evaluate the levels of the heavy subunit of neurofilament (NF-H) and soluble TNF receptor 1 (sTNFR1) in cerebrospinal fluid (CSF) as biomarkers of clinical severity of subacute sclerosing panencephalitis (SSPE), concentrations of NF-H and sTNFR1 in CSF of 34 patients with SSPE and in control subjects were measured by ELISA. The CSF NF-H levels were significantly higher in patients with SSPE than in controls (p < 0.0001), and those in patients in Jabbour stage III were significantly higher than in patients in stage II (p = 0.015). The CSF sTNFR1 levels in SSPE patients were significantly higher than those in controls (p = 0.004), but there were no significant differences in CSF sTNFR1 levels between patients in Jabbour stages II and III. There was a significant correlation between CSF NF-H and sTNFR1 levels in patients with SSPE (p = 0.011). We suggest that CSF NF-H levels can be used as a marker of development of neuronal degeneration in SSPE, and that TNF-α modifies the neurodestructive pathogenesis in SSPE.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 205, Issues 1â2, 15 December 2008, Pages 155-159
Journal: Journal of Neuroimmunology - Volume 205, Issues 1â2, 15 December 2008, Pages 155-159
نویسندگان
Takeshi Matsushige, Takashi Ichiyama, Banu Anlar, Jun Tohyama, Keiko Nomura, Yushiro Yamashita, Susumu Furukawa,