کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065195 | 1580465 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis](/preview/png/3065195.png)
چکیده انگلیسی
Classical complement pathway factor, C4 is required for experimental autoimmune myasthenia gravis (EAMG) pathogenesis. C4 is also a central component of the mannose binding lectin (MBL) pathway suggesting that this pathway might also be involved in MG pathogenesis. However, MBL gene deficient mice displayed intact anti-acetylcholine receptor (AChR)-immune response and neuromuscular junction (NMJ) IgG and complement accumulation following AChR-immunization. Moreover, no significant difference was observed between the serum MBL levels of 77 anti-AChR antibody positive generalized MG patients and 105 healthy controls. Therefore, MBL pathway does not play a role in EAMG/MG pathogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 208, Issues 1â2, 31 March 2009, Pages 40-45
Journal: Journal of Neuroimmunology - Volume 208, Issues 1â2, 31 March 2009, Pages 40-45
نویسندگان
Jing Li, Huibin Qi, Erdem Tüzün, Windy Allman, Vuslat Yılmaz, Shamsher S. Saini, Feza Deymeer, Güher Saruhan-Direskeneli, Premkumar Christadoss,