کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3065209 | 1580465 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD8 positive T-cell infiltration in the dentate nucleus of paraneoplastic cerebellar degeneration
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: CD8 positive T-cell infiltration in the dentate nucleus of paraneoplastic cerebellar degeneration CD8 positive T-cell infiltration in the dentate nucleus of paraneoplastic cerebellar degeneration](/preview/png/3065209.png)
چکیده انگلیسی
Recent reports have discussed the presence of cytotoxic T cells in paraneoplastic cerebellar degeneration (PCD). We report an autopsy case of PCD associated with anti-Hu antibody, in which we revealed infiltration of CD8+ T cells in and around the dentate nucleus but not in the cerebellar cortex, in addition to severe Purkinje cell loss. Some infiltrated mononuclear cells expressed cytotoxic cell marker, Granzyme B. Decrease of neurons and reduced presynapses were demonstrated in the dentate nucleus. This is the first report that suggests the possibility of the dentate nucleus being primarily attacked followed by Purkinje cell loss in PCD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 208, Issues 1–2, 31 March 2009, Pages 136–140
Journal: Journal of Neuroimmunology - Volume 208, Issues 1–2, 31 March 2009, Pages 136–140
نویسندگان
Moe Moe Aye, Takefumi Kasai, Yukie Tashiro, Hui Qin Xing, Hiroshi Shirahama, Minoru Mitsuda, Takayuki Suetsugu, Keiko Tanaka, Mitsuhiro Osame, Shuji Izumo,