کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065226 1580471 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
BAFF is up-regulated in central nervous system of neuro-Behçet's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
BAFF is up-regulated in central nervous system of neuro-Behçet's disease
چکیده انگلیسی

We report that B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed in central nervous system (CNS) of neuro-Behçet's disease (NBD). This study investigated BAFF and BAFF-R (BAFF receptor) in NBD, compared to multiple sclerosis (MS) and to non inflammatory neurological diseases (NIND). Cerebrospinal fluid (CSF) was used to determine the level of BAFF messenger RNA (mRNA) and the level of BAFF-R mRNA in unfractionated cells. A sandwich ELISA was used to quantify soluble BAFF protein levels in serum and in CSF. BAFF and BAFF-R expression in CSF were increased in NBD and MS patients compared to NIND patients. RNA levels of BAFF and BAFF-R were significantly correlated in NBD and MS patients. Serum sBAFF levels were increased in NBD and MS patients, but did not correlate with BAFF expression in CSF. CNS-produced BAFF may support inflammatory cell survival in NBD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 200, Issues 1–2, 30 August 2008, Pages 111–114
نویسندگان
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