کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065333 1580478 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of multiple sclerosis cerebrospinal fluid reveals a continuum of clonally related antibody-secreting cells that are predominantly plasma blasts
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Analysis of multiple sclerosis cerebrospinal fluid reveals a continuum of clonally related antibody-secreting cells that are predominantly plasma blasts
چکیده انگلیسی

Fluorescence-activated cell sorting (FACS) analysis of B cell subtypes in 17 CSF samples from 15 patients with clinically-definite MS revealed that CD19+ B cells accounted for 2 to 11% (mean 5%) and CD138+ cells constituted 0 to 5% (mean 2%) of total CSF lymphocytes. Further stratification of CD138+ cells based on expression levels of CD19 showed that CD138+19+ plasma blasts constituted 89 ± 2% (mean ± SE) of the CD138+ cell population (P < 0.00001), with more mature plasma cells (CD138+19−) constituting the remaining 11 ± 2%. Sequence analysis of immunoglobulin variable regions in single CD138+19+ and CD138+19− cells sorted from MS CSF identified many of the same clonal populations in both populations, indicating a continuum of clonally related plasma cell subtypes of which CD138+19+ plasma blasts are most abundant.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 192, Issues 1–2, December 2007, Pages 226–234
نویسندگان
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