کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3065356 1580476 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TNF and sTNFR1/2 plasma levels in ALS patients
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
TNF and sTNFR1/2 plasma levels in ALS patients
چکیده انگلیسی

The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subjects. The genetic analysis of the polymorphisms of TNF-alpha, TNF-R1 and TNF-R2 showed no statistically significant differences in alleles and genotype frequencies between patients and controls. These data suggest a participation of the immune system in response to as far unknown intracellular signals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 194, Issues 1–2, February 2008, Pages 123–131
نویسندگان
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